Michael Shum Selected Research

PF-4708671

1/2019	Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.
3/2016	Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice.

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Michael Shum Research Topics

Disease

6	Insulin Resistance 11/2021 - 10/2013
3	Obesity 01/2021 - 03/2016
2	Neoplasms (Cancer) 01/2023 - 12/2020
2	Non-alcoholic Fatty Liver Disease 01/2021 - 01/2021
1	Alcoholic Hepatitis 01/2024
1	Inflammation (Inflammations) 01/2024
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2024
1	Prostatic Neoplasms (Prostate Cancer) 10/2023
1	Hyperglycemia 01/2021
1	Hypothermia 12/2020
1	Glucose Intolerance 03/2016
1	Body Weight (Weight, Body) 01/2016

Drug/Important Bio-Agent (IBA)

5	Insulin (Novolin)FDA Link 01/2021 - 10/2013
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 10/2013
2	Biliverdine (Biliverdin)IBA 01/2024 - 01/2021
2	AntioxidantsIBA 01/2021 - 01/2021
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 03/2016
2	PF-4708671IBA 01/2019 - 03/2016
1	Androgen Receptors (Androgen Receptor)IBA 10/2023
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 10/2023
1	LipidsIBA 11/2021
1	CarbonIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Sterol Regulatory Element Binding Protein 1IBA 01/2021
1	BilirubinIBA 01/2021
1	CalciumIBA 12/2020
1	Estrogens (Estrogen)FDA Link 12/2020
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 03/2016
1	TOR Serine-Threonine KinasesIBA 03/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 03/2016
1	Sirolimus (Rapamycin)FDA Link 03/2016
1	AngiotensinsIBA 01/2016
1	LeptinIBA 01/2016
1	Blood Glucose (Blood Sugar)IBA 01/2016

Therapy/Procedure

3	Therapeutics 01/2023 - 12/2020
1	Liver Transplantation 01/2024